PeReNE

Différenciation et Communication Neuronale et Neuroendocrine

INSERM U982 - Equipe Facteurs neurotrophiques et différenciation neuronale

Research team

INSERM DR LILLE, UNIVERSITY OF ROUEN

David VAUDRY
david.vaudry@univ-rouen.fr

INSERM U982
University of Rouen
Place E. Blondel
76821
Mont-Saint-Aignan
http://proger-cdd.crihan.fr

Research interest:

Mechanisms involved in the development of the cerebellar cortex: The focus is on peptides, proteins of the extracellular matrix and neurosteroids controlling the proliferation, migration, differentiation and survival of cerebellar granule cells. Use of peptides and stem cells expressing peptides for the treatment of stroke: The focus is on the effect on peptides on the infarct volume, apoptosis, oxidative stress, inflammatory response and functional recovery related to brain ischemia. Investigation of the toxic effects of alcohol on the brain in a model of Alcohol Foetal Syndrom (AFS) and in a model of Binge Drinking: The focus is on the effect of peptides on oxidative stress, cell death and neurological deficits induced by ethanol exposure

Key words: Differentiation, Stroke, Peptides, Cerebellar granule cells, Binge Drinking

Main publications over the last few years:

22927932

Hamdi Y, Kaddour H, Vaudry D, Bahdoudi S, Douiri S, Leprince J, Castel H, Vaudry H, Tonon MC, Amri M and Masmoudi-Kouki O. The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PLoS One 2012, 7: e42498. doi.

22411806

Fahrion JK, Komuro Y, Li Y, Ohno N, Littner Y, Raoult E, Galas L, Vaudry D and Komuro H. Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proc Natl Acad Sci U S A 2012, 109: 5057-62.

22308338

Li Y, Komuro Y, Fahrion JK, Hu T, Ohno N, Fenner KB, Wooton J, Raoult E, Galas L, Vaudry D and Komuro H. Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling. Proc Natl Acad Sci U S A 2012, 109: 2630-5.

22289055

Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, Vaudry D, Vaudry H, Waschek JA and Said SI. Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol 2012, 166: 4-17. doi.

21919910

Raoult E, Roussel BD, Bénard M, Lefebvre T, Ravni A, Ali C, Vivien D, Komuro H, Fournier A, Vaudry H, Vaudry D and Galas L. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP. J Neurochem 2011, 119: 920-31. doi.

21524253

Bourgault S, Chatenet D, Wurtz O, Doan ND, Leprince J, Vaudry H, Fournier A and Vaudry D. Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug. Curr Pharm Des 2011, 17: 1002-24.