Différenciation et Communication Neuronale et Neuroendocrine

INSERM U982 - Equipe Facteurs neurotrophiques et différenciation neuronale

Research team



University of Rouen
Place E. Blondel

Research interest:

Mechanisms involved in the development of the cerebellar cortex: The focus is on peptides, proteins of the extracellular matrix and neurosteroids controlling the proliferation, migration, differentiation and survival of cerebellar granule cells. Use of peptides and stem cells expressing peptides for the treatment of stroke: The focus is on the effect on peptides on the infarct volume, apoptosis, oxidative stress, inflammatory response and functional recovery related to brain ischemia. Investigation of the toxic effects of alcohol on the brain in a model of Alcohol Foetal Syndrom (AFS) and in a model of Binge Drinking: The focus is on the effect of peptides on oxidative stress, cell death and neurological deficits induced by ethanol exposure

Key words: Differentiation, Stroke, Peptides, Cerebellar granule cells, Binge Drinking

Main publications over the last few years:


Hamdi Y, Kaddour H, Vaudry D, Bahdoudi S, Douiri S, Leprince J, Castel H, Vaudry H, Tonon MC, Amri M and Masmoudi-Kouki OThe octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PLoS One 2012, 7e42498. doi.


Fahrion JK, Komuro Y, Li Y, Ohno N, Littner Y, Raoult E, Galas L, Vaudry D and Komuro HRescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proc Natl Acad Sci U S A 2012, 1095057-62.


Li Y, Komuro Y, Fahrion JK, Hu T, Ohno N, Fenner KB, Wooton J, Raoult E, Galas L, Vaudry D and Komuro HLight stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling. Proc Natl Acad Sci U S A 2012, 1092630-5.


Harmar AJ, Fahrenkrug J, Gozes I, Laburthe M, May V, Pisegna JR, Vaudry D, Vaudry H, Waschek JA and Said SIPharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol 2012, 1664-17. doi.


Raoult E, Roussel BD, Bénard M, Lefebvre T, Ravni A, Ali C, Vivien D, Komuro H, Fournier A, Vaudry H, Vaudry D and Galas LPituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP. J Neurochem 2011, 119920-31. doi.


Bourgault S, Chatenet D, Wurtz O, Doan ND, Leprince J, Vaudry H, Fournier A and Vaudry DStrategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug. Curr Pharm Des 2011, 171002-24.

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